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The SCN receives light input directly from the retina and conveys time-of-day signals to peripheral clocks throughout the body, ensuring systemic synchronization ( At the molecular level, circadian rhythms are primarily driven by transcriptional-translational feedback loops (TTFLs) and rhythmic posttranslational modifications, such as phosphorylation and ubiquitination (Mendoza-Viveros et al., 2017)

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These substrates include lipid metabolism disorders, elevated blood pressure, chronic inflammation, cardiac structural remodeling, and electrophysiological abnormalities (Middeldorp et al., 2023)

doi: 10.1097/01.bor.0000171215.87993.6b